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Ask HN: What is the latest on treatment of Metastatic Breast Cancer?

(news.ycombinator.com)

28 points

by: hazrmard

7 days ago

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I was reading this recently shared post on the promise of CAR-T therapy for cancer[1]. However, it seems that it may not be universally applicable to all cancers[2], including breast cancer.

What have we discovered (and made available as treatment) for advanced breast cancers?

[1]: https://news.ycombinator.com/item?id=44219379 [2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC8990477/

10 comments

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pella

7 days ago

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Not a doctor, but gut microbiome modulation (e.g. fecal microbiota transplantation) is one of the most talked-about adjuncts for (metastatic breast) cancer right now.
https://scholar.google.com/scholar?as_ylo=2022&q=fecal+micro...
--- example:
"Understanding the relationship between breast cancer, immune checkpoint inhibitors, and gut microbiota: a narrative review"
https://pmc.ncbi.nlm.nih.gov/articles/PMC11557166/ ( Transl Breast Cancer Res. 2024 Oct 21)
```
  """
  Conclusions
  The composition of gut microbiota could help predict 
  the chance of response to immunotherapy, 
  and modulating gut microbiota has the potential 
  to enhance the  efficacy of chemo-immunotherapy 
  in breast cancer. 
  However, the available data relating to breast cancer 
  are limited. 
  Larger prospective studies are required 
  to further elucidate their role 
  as a biomarker and treatment.
  """
```
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yread

7 days ago

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Depends on a lot of things. Subtype, ER, PR, HER2? For triple negative breast cancers some patients may avoid chemo if they have highly active immune system (TILs)
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incomingpain

6 days ago

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Step 1: See Oncologist and take their advice.
Step 2: Definitely don't take internet advice. Disregard the following.
Step 3: Hit the gym
Step 4: Intermittent fasting + 50% fat, 50% protein diet.
Step 5: Ask doctor for a standard run of Fenbendazole or Mebendazole
Step 6: Play with them as much as possible.
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anonzzzies

6 days ago

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<@incomingpain> > Step 2: Definitely don't take internet advice.
then
> Step 4: Intermittent fasting + 50% fat, 50% protein diet.
> Step 5: Ask doctor for a standard run of Fenbendazole or Mebendazole
Right...
So definitely don't listen to this then.
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incomingpain

6 days ago

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<@anonzzzies> That's literally the joke... Good job.
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anonzzzies

6 days ago

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<@incomingpain> Funny, considering there are boatloads of crackpots even on HN who actually believe this would work and advocate it all the time. I haven't heard from that dude who comments on everything with that he and his family only eat beef for a while so I assume they died of that great keto diet.
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seattle_spring

5 days ago

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<@anonzzzies> > I haven't heard from that dude who comments on everything with that he and his family only eat beef for a while
Didn't know Jordan Peterson was on HN.
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nextos

5 days ago

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Look into companies doing trials with a credible track record. For example, Immunocore has good T cell receptor designs to bind common antigens in breast cancer tumors. For solid tumors, including breast cancer, the protein ID is IMC-F106C. For advanced cases, this is usually combined with a checkpoint inhibitor.
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g42gregory

7 days ago

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Here is a possibly different (or supplemental) point of view, with repurposed drugs and metabolic interventions. I believed it would be applicable to the breast cancers: https://imahealth.org/research/cancer-care/
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hazrmard

6 days ago

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<@g42gregory> Thank you very much! I had been reading up on effect of diet for treatment & management. I like the focus on citations.
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